Pandemic 2

In Pandemic 2, you’re not saving the world — you’re ending it. This darkly fascinating strategy simulation puts you in control of a virus, parasite, or bacteria, and tasks you with one goal: wipe out humanity before they can respond. With evolving symptoms, resistances, and global travel patterns, every game becomes a chilling exercise in infectious domination. It’s one of Flash gaming’s most infamous classics — and now it’s back, ready to spread.

How to play Pandemic 2

In Pandemic 2, you’ll design and evolve a disease to bring the world to its knees. Your mission is to infect every region and eliminate the human population before they can develop a cure or shut down travel. Strategy and patience are key.

Getting Started

Choose your pathogen type: virus, bacteria, or parasite — each has unique traits in terms of mutation rates, resistances, and visibility. Once selected, your disease starts in a random country.

Managing Your Disease

Use evolution points to upgrade your symptoms (like fever, vomiting, or organ failure), resistances (heat, cold, drugs), and transmission methods (water, air, insects). The key is balancing lethality and stealth. If your disease is too deadly too early, countries will respond fast and isolate themselves.

Watching the World React

Track global news events and monitor country statuses. Governments may close borders, shut down airports, and deploy vaccines if your disease becomes too obvious. Madagascar is notoriously hard to infect — a rite of passage for Pandemic 2 players is getting that final stubborn island.

Game Over Conditions

You win when the global population hits zero. You lose if your disease is eradicated or if humans survive long enough to develop a full cure and shut you down.

Controls

• Desktop only: Mouse-only interface. Click to evolve traits, view world data, and manage your outbreak.

FAQ

How do I infect every country, especially hard ones like Madagascar?

Focus on water and air transmission early, and avoid lethal symptoms until all countries are infected. Start with subtle symptoms to stay undetected and keep borders open longer.

What’s the difference between virus, bacteria, and parasite?

Viruses mutate quickly, making them hard to control. Bacteria have balanced traits. Parasites are very stealthy but evolve more slowly. Choose based on your preferred strategy.

What triggers governments to shut down borders or deploy vaccines?

Visible or severe symptoms like coughing, vomiting, and death will trigger responses. Keep symptoms mild and invisible (like fatigue or sneezing) to stay under the radar early.

Can I win if some countries close their borders early?

It’s difficult. If key transport hubs (like airports or shipyards) close early, you may never reach isolated countries. Restarting the game with a new starting point may help.

Is there a cure in the game?

Yes, but it’s not always deployed. If your disease becomes too visible or deadly, countries may begin researching a vaccine. You must act fast to finish them off.

Can I save and resume my game?

No, Pandemic 2 does not support mid-game saving. Each run must be completed in a single session.